Jazz Pharmaceuticals plc
JAZZJazz Pharmaceuticals plc's three tracks disagree. Price, valuation and the earnings engine each tell a different story — the next quarter or two settles it.
The sharpest disagreement: the price moved +126.5% in a year while annual EPS moved −167.5% — the difference is re-rating, and re-rating has to be repaid with earnings.
The price is in a confirmed uptrend (51 weeks in) while the P/E sits at the 49th percentile of its own 2-year range. Underneath, the last four quarters read improving, and 254% of the last 2 years' profit arrived as cash. What settles it: whether earnings grow into a price that has already moved.
Price story Before the numbers, the tape. A stock price moves through four repeating seasons: a flat base (stage 1), an advance (2), a top (3), a decline (4). Where the price sits in that cycle frames everything below.
Jazz Pharmaceuticals plc trades at $262, in a confirmed uptrend and 51 weeks into that stage. That is +35.9% against its own 200-day average. It sits at 100% of a 52-week range of $118 to $262. On relative strength it has been ahead of the S&P 500 on a trailing-13-week view for 24 straight weeks.
Today the stock is in a confirmed uptrend — week 51 of stage 2. At $262 it trades +35.9% versus its 200-day average and sits at 100% of its 52-week range ($118–$262).
Against the market, two honest reads. Cumulative: over the last 10.1 years the stock moved +87% while the S&P 500 moved +263% — behind the index over the full window. Recent form: on a trailing-13-week view the stock has been ahead for 24 straight weeks — the ribbon below is that same metric, week by week.
What would end the trend, mechanically: two Friday closes in a row below the 200-day line. That is the exit rule — no debates.
Valuation P/E is the price of $1 of annual profit: how many dollars the market pays for each dollar the company earns in a year.
Jazz Pharmaceuticals plc trades at 17.9× P/E, mid-range by its own standards (49th percentile). Its long-run median P/E is 18.1×, measured across 2.1 years of weekly readings. This places the multiple against the stock’s own record, and says nothing about what the business is worth.
Today's P/E of 17.9× is mid-range by its own standards (49th percentile), against a long-run median of 18.1× measured over 2.1 years of weekly readings. This is a comparison against the stock's own history — not a claim about what it is worth.
🚨 Why the multiple sits where it does: over the past year annual EPS moved −167.5% against a +126.5% price move — the price outran earnings, pushing the multiple UP its own range.
Put together: the multiple is unremarkable against its own past, so the story rests on the earnings line underneath it, not the multiple.
Stage: Turning around Every business sits somewhere on a fundamental arc, and this page names the spot before anything else. The last twelve quarters of revenue, profit and EPS growth — plus the return the business earns on its capital — are read as curves: Deteriorating (the curves are falling), Turning around (a trough has just formed and the last few quarters lift off it), Improving (the climb off the trough is sustained), Consistent (steadily positive with healthy returns), Topping out (still high but decelerating from the peak). When the curves genuinely disagree the read is Mixed; too little history is No read. CAGR (compound annual growth rate) is the smooth yearly pace that turns the starting value into the latest one — the fairest way to compare growth across different time spans. Read the columns together: if the 1-year number towers over the 10-year, recent growth is running hotter than the long-run trend. A dash means that window is not held, or the base year was a loss (where a growth rate is not meaningful).
Jazz Pharmaceuticals plc reads as turning around on its fundamental arc. Turning around — profit growth swung from −43.2% at the trough to +5.3% off a 2-quarter-old trough (single-quarter readings), ROCE holding at 5.9%. The read is built from 12 quarters across 3 curves, on partial evidence.
Why it matters: growth inflections are where re-ratings start — the curves say a turn is forming, so the question becomes whether the next quarters confirm it.
One or more growth curves carry a base-effect spike — a large year-on-year move off a near-zero or loss-making comparable quarter. Those spikes are capped before the classifier reads the trajectory, and shown pinned on the chart, so a single distorted quarter does not drive the stage call.
A partial read: at least one curve is short, or the returns curve is not the computed quarterly series — hold the stage word a little more loosely.
| 1yr | 3yr | 5yr | 10yr | |
|---|---|---|---|---|
| Revenue | +4.9% | +5.3% | — | — |
| Stock price | +126.5% | +26.2% | +11.8% | +5.7% |
4-Factor Sector Score
63.0/100 — rank 2 of 30 in Biotechnology · 74% evidence confidence
Jazz Pharmaceuticals plc scores 63.0 out of 100 against the 30 companies it is compared with in Biotechnology, ranking 2. Balanced evidence: keep at normal research priority and require another comparable period before raising conviction.
The four contributions add to the total exactly: 21.5 + 12.3 + 14.2 + 15 = 63. This is the SAME number shown on the sector comparison — it is computed once, for the whole peer set, and read here.
What would change it: The read weakens if profit growth turns negative or margin improvement reverses while sector-relative strength deteriorates.
Revenue Revenue is the top line: everything the company billed its customers in the period.
Jazz Pharmaceuticals plc reported $1.1 B of revenue in the Mar 26 quarter, +18.9% year on year. That is the 4th straight quarter of year-on-year growth. Over 4 years it has compounded at 8.4% a year. The last full year, FY25, came in at $4.3 B. The last four reported quarters add to $4.5 B.
FY25 revenue came in at $4.3 B (+4.9% on the year), capping 4 years at 8.4% compound. The latest quarter (Mar 26) printed $1.1 B, +18.9% year on year — the 4th consecutive quarter of year-over-year growth.
Pace check: the last four quarters averaged +9.9% growth against the decade's 8.4% — the current year is running faster than its own long-run rate.
Acceleration check: trailing-twelve-month revenue grew +9.6% over the last 4 quarters against +7.7%/yr over the last 8 — stabilising; TTM profit −95.9% vs −75.7%/yr — rolling over.
Operating margin Operating margin is what is left of every $100 of sales after running the business, before interest and tax. It is the cleanest read on pricing power and cost control.
Jazz Pharmaceuticals plc's operating margin is 31.8% in the Mar 26 quarter, +38.5 percentage points against the same quarter a year ago. Across 5 fiscal years the operating margin has ranged −10.1% to 17.7%. The current quarter is running above every full year in that window.
The latest quarter's operating margin is 31.8%, +38.5 pp against the same quarter a year ago. Across 5 fiscal years the operating margin has ranged −10.1%–17.7%.
Why the margin moved: operating margin went +38.5 pp year on year while gross margin went −0.9 pp — the gain came mostly below the gross line: operating leverage, with costs spread over a bigger revenue base.
Net profit Net profit is what survives every cost, interest and tax — the number EPS, dividends and book value all grow from.
Jazz Pharmaceuticals plc earned $0.3 B of net profit in the Mar 26 quarter. The full FY25 year was a loss of $0.4 B. That is 27.1% of the quarter's revenue. The same quarter a year earlier lost $0.1 B. 3 of the last 12 reported quarters were loss-making.
Mar 26 profit was $0.3 B, null year on year. On the full year, FY25 printed $−0.4 B (−164.3%).
Pace comparison, last four quarters: profit −168.2% vs revenue +9.9%. Profit is growing slower than sales — costs are eating the growth before it reaches the bottom line.
Cash flow — the router The P&L says what was earned; the cash-flow statement says what actually arrived. Operating cash flow (CFO) against profit is the cleanest lie detector in the accounts.
Over the last 2 fiscal years 254% of Jazz Pharmaceuticals plc's reported profit arrived as operating cash — the cash follows the profit. In FY25 that was $1.4 B of operating cash against $−0.4 B of profit. After $0.1 B of capital spending, $1.3 B was left as free cash.
FY25: operating cash of $1.4 B against reported profit of $−0.4 B, leaving free cash of $1.3 B after $0.1 B of capital spending. Across the last 2 fiscal years the conversion rate is 254% of profit.
Cash-flow readings here are annual — that is the resolution our series carries, so this section moves once a year.
Why: conversion is measured cleanly, but the working-capital day-counts behind it sit below what we hold — the move is shown without inventing its driver.
Router verdict: the visible cash user is investment — the next section checks what the spending is buying.
Where the cash goes Working capital is the cash tied up between paying suppliers and getting paid: debtor days (customers owe), inventory days (stock waits), and the cash conversion cycle (the whole loop, in days of sales).
Jazz Pharmaceuticals plc does not report the debtor, inventory and payable day-counts a cash cycle is built from, so this section reads the investment side instead. Capital spending ran $0.0 B over the last 3 years. Averaged over those years that is 0.0% of FY25 revenue a year.
Working-capital day-counts are not in our numbers for this stock, so this section reads the investment side — where the cash is being put to work.
On the investment side: capital spending of $0.0 B over the last 3 fiscal years.
The synthesis: the cash is going into capacity, not disappearing into the cycle — the question becomes whether the new capacity earns.
Return on equity Return on equity (ROE) is the profit the business earns on its shareholders’ money. With the full capital-employed split not in our numbers, ROE is the cleanest long ladder we can draw here.
Jazz Pharmaceuticals plc earns a ROE of −8% in FY25. That is up from a trough of −8% in FY21. Return on invested capital clears the cost of that capital by +11.3 percentage points, so growth here adds value rather than only size. The wiring behind it is −8.4% net margin on 0.37× asset turns.
FY25 ROE is −8%, recovered from a FY21 trough of −8% — the full ladder below shows the fall and the climb, undoctored.
Why the return is what it is — the wiring (FY25): −8.4% net margin × 0.37× asset turns × 2.70× balance-sheet leverage ≈ −8.4% on equity. Margin does its share; leverage is a meaningful part of the equation.
The capstone test — ROIC − WACC: 17.2% − 5.9% = a +11.3 pp spread. The 5.9% is an estimate of this company's own cost of capital — read the sign and the size of the spread, not the decimals. A spread this wide means every dollar reinvested creates more than a dollar of value — the engine compounds.
Dividend
Jazz Pharmaceuticals plc pays no dividend. Across the last 12 reported quarters it has declared no dividend per share, so there is no payout history to chart and no yield to quote. Companies at this stage typically reinvest earnings rather than distribute them, which makes the cash-flow and reinvestment sections the place that cash shows up.
Jazz Pharmaceuticals plc does not currently pay a dividend. Across the last 12 reported quarters the company has declared no dividend per share, so there is no payout history to chart and no yield to quote. Companies at this stage typically reinvest earnings instead of distributing them.
Debt Debt-to-equity says how much of the business is funded by borrowings. Low is the safe corner; the trend matters as much as the level.
Jazz Pharmaceuticals plc carries total debt of $5.4 B against shareholder equity of $4.5 B as of Mar 26, a debt-to-equity of 1.19. On the annual view that ratio went from 1.55 in FY21 to 1.25 in FY25. Read the returns elsewhere on this page with that leverage in mind.
Mar 26: total debt of $5.4 B against shareholder equity of $4.5 B — a debt-to-equity of 1.19. On the annual view, debt-to-equity went from 1.55 (FY21) to 1.25 (FY25). Read the returns on this page with that leverage in mind.
Ownership There is no quarter-by-quarter holder register to read here, so we read the crowd through short interest — the slice of tradable shares currently sold short, positioned for a fall.
6.3% of Jazz Pharmaceuticals plc's tradable float is currently sold short — some money is positioned against it. At typical trading volumes those positions would take about 4.4 days to buy back. There is no quarter-by-quarter holder register to read for this filer, so the crowd is read through short interest instead.
The latest reading: 6.3% of the float is sold short, and at typical trading volumes it would take about 4.4 days to buy those positions back. Some money is positioned against it. This is a single point-in-time reading — we do not yet hold its history, so we show no trend chart.
Why it sits there: who is doing the shorting, and why, does not travel with the number — the level is shown without inventing its story.
Safety line The Z-score estimates how far a company sits from balance-sheet distress — above roughly 3 is safe, below roughly 1.8 is the danger zone. It was built for manufacturers, so it is not applied to banks and lenders.
Jazz Pharmaceuticals plc: the Z-score reads 2.08. A Z-score above roughly 3 reads as safe and below roughly 1.8 as the distress zone, so this sits in the grey band between the two. It is a distance-to-distress estimate from the balance sheet, not a forecast of failure.
Why it matters: a Z-score of 2.08 sits in the grey band — neither clearly safe nor clearly distressed.
The safety line in one sentence: the Z-score reads 2.08.
| Company | Score | Price stage | Growth & earnings/35 | Capital efficiency/25 | Valuation/20 | Relative strength/20 |
|---|---|---|---|---|---|---|
| 1Exelixis, Inc.EXEL | 64.3/100Thin evidence · provisional56% evidence | LEADER | 20.7/35 Revenue — · PAT — · OPM change 7.5 pp 39% evidence | 17.2/25 ROCE 10.8% · OPM 41.1% 76% evidence | 11.3/20 P/E 14× · PEG — 15% evidence | 15.1/20 RS sector 0.7% · RS bench 12.5% · 1Y 48.5%11 of 12 weeks ahead 100% evidence |
| Exact sum: 20.7 + 17.2 + 11.3 + 15.1 = 64.3 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 2Jazz Pharmaceuticals plcthis pageJAZZ | 63.0/100Mixed-positive evidence74% evidence | LEADER | 21.5/35 Revenue 9.2% · PAT -93.8% · OPM change 37.7 pp 62% evidence | 12.3/25 ROCE 3.4% · OPM 31.5% 76% evidence | 14.2/20 P/E 16.6× · PEG 0.33 65% evidence | 15.0/20 RS sector 17.7% · RS bench 30.2% · 1Y 135.1%12 of 12 weeks ahead 100% evidence |
| Exact sum: 21.5 + 12.3 + 14.2 + 15 = 63 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 3Krystal Biotech, Inc.KRYS | 60.7/100Mixed-positive evidence81% evidence | FADING | 22.9/35 Revenue 25.2% · PAT 80.7% · OPM change 5 pp 83% evidence | 13.2/25 ROCE 4.7% · OPM 46.1% 76% evidence | 12.5/20 P/E 34.5× · PEG 0.8 65% evidence | 12.1/20 RS sector 4.9% · RS bench 15.6% · 1Y 134.2%10 of 12 weeks ahead 100% evidence |
| Exact sum: 22.9 + 13.2 + 12.5 + 12.1 = 60.7 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 4Halozyme Therapeutics, Inc.HALO | 58.9/100Mixed-positive evidence81% evidence | BREAKING OUT | 15.9/35 Revenue 39.2% · PAT -28.3% · OPM change -4.4 pp 83% evidence | 16.8/25 ROCE 8.5% · OPM 49% 76% evidence | 15.0/20 P/E 23.2× · PEG 0.27 65% evidence | 11.2/20 RS sector -5.9% · RS bench 6.1% · 1Y 32.3%6 of 12 weeks ahead 100% evidence |
| Exact sum: 15.9 + 16.8 + 15 + 11.2 = 58.9 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 5Incyte CorporationINCY | 58.9/100Thin evidence · provisional58% evidence | BREAKING OUT | 17.4/35 Revenue — · PAT — · OPM change 4.2 pp 45% evidence | 17.7/25 ROCE 12.6% · OPM 23.7% 76% evidence | 11.2/20 P/E 14.4× · PEG — 15% evidence | 12.6/20 RS sector -2.1% · RS bench 9.5% · 1Y 53.8%8 of 12 weeks ahead 100% evidence |
| Exact sum: 17.4 + 17.7 + 11.2 + 12.6 = 58.9 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 6Roivant Sciences Ltd.ROIV | 57.7/100Thin evidence · provisional60% evidence | BREAKING OUT | 20.2/35 Revenue -69% · PAT — · OPM change 20242.2 pp 62% evidence | 12.2/25 ROCE 7.8% · OPM — 61% evidence | 11.5/20 P/E 2× · PEG — 15% evidence | 13.8/20 RS sector 16.6% · RS bench 28.1% · 1Y 201%7 of 12 weeks ahead 100% evidence |
| Exact sum: 20.2 + 12.2 + 11.5 + 13.8 = 57.7 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 7Corcept Therapeutics IncorporatedCORT | 57.6/100Thin evidence · provisional58% evidence | LEADER | 17.0/35 Revenue — · PAT — · OPM change -32.3 pp 45% evidence | 12.7/25 ROCE 5.9% · OPM -30.1% 76% evidence | 8.5/20 P/E 207× · PEG — 15% evidence | 19.4/20 RS sector 33.3% · RS bench 50.7% · 1Y 51.9%12 of 12 weeks ahead 100% evidence |
| Exact sum: 17 + 12.7 + 8.5 + 19.4 = 57.6 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 8Vertex Pharmaceuticals IncorporatedVRTX | 55.5/100Mixed-positive evidence74% evidence | BREAKING OUT | 21.1/35 Revenue 10.1% · PAT — · OPM change 15.4 pp 62% evidence | 15.1/25 ROCE 5.5% · OPM 38.1% 76% evidence | 10.9/20 P/E 26.5× · PEG 1.2 65% evidence | 8.4/20 RS sector -13.5% · RS bench -3.1% · 1Y 30.6%5 of 12 weeks ahead 100% evidence |
| Exact sum: 21.1 + 15.1 + 10.9 + 8.4 = 55.5 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 9Royalty Pharma plcRPRX | 55.4/100Mixed-positive evidence81% evidence | LEADER | 12.1/35 Revenue 7.8% · PAT -23.1% · OPM change -4.7 pp 83% evidence | 13.5/25 ROCE 3.2% · OPM 89.3% 76% evidence | 14.3/20 P/E 25.1× · PEG 0.29 65% evidence | 15.5/20 RS sector 3.7% · RS bench 15.4% · 1Y 53%11 of 12 weeks ahead 100% evidence |
| Exact sum: 12.1 + 13.5 + 14.3 + 15.5 = 55.4 · Decision use: Price leads the evidence: RS versus the benchmark is 15.4%, but earnings trajectory is weak. Wait for revenue and profit confirmation. | ||||||
| 10Regeneron Pharmaceuticals, Inc.REGN | 49.2/100Thin evidence · provisional58% evidence | TURNING | 16.8/35 Revenue — · PAT — · OPM change -1.7 pp 45% evidence | 13.5/25 ROCE 3.7% · OPM 17.8% 76% evidence | 11.0/20 P/E 15.4× · PEG — 15% evidence | 7.9/20 RS sector -11.6% · RS bench -1.1% · 1Y 35.1%1 of 12 weeks ahead 100% evidence |
| Exact sum: 16.8 + 13.5 + 11 + 7.9 = 49.2 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 11Genmab A/SGMAB | 49.1/100Mixed-negative evidence81% evidence | TURNING | 14.9/35 Revenue 27.5% · PAT -19.9% · OPM change -6.2 pp 83% evidence | 12.8/25 ROCE 2.1% · OPM 20.1% 76% evidence | 15.7/20 P/E 20.4× · PEG 0.24 65% evidence | 5.7/20 RS sector -19.9% · RS bench -9.8% · 1Y 35.4%2 of 12 weeks ahead 100% evidence |
| Exact sum: 14.9 + 12.8 + 15.7 + 5.7 = 49.1 · Decision use: Cheap but unconfirmed: require improving earnings before treating the valuation as an opportunity. | ||||||
| 12argenx SEARGX | 48.8/100Thin evidence · provisional58% evidence | TURNING | 20.1/35 Revenue — · PAT — · OPM change 12.8 pp 45% evidence | 13.6/25 ROCE 6.8% · OPM 30% 76% evidence | 9.8/20 P/E 35.6× · PEG — 15% evidence | 5.3/20 RS sector -16.7% · RS bench -6.6% · 1Y 27.6%7 of 12 weeks ahead 100% evidence |
| Exact sum: 20.1 + 13.6 + 9.8 + 5.3 = 48.8 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 13BeOne Medicines AGONC | 48.2/100Mixed-negative evidence64% evidence | BASING | 22.9/35 Revenue 37.4% · PAT — · OPM change 15.5 pp 62% evidence | 11.1/25 ROCE 4.7% · OPM 16.5% 76% evidence | 9.0/20 P/E 69.2× · PEG — 15% evidence | 5.2/20 RS sector -18.8% · RS bench -8.2% · 1Y 12.1%0 of 12 weeks ahead 100% evidence |
| Exact sum: 22.9 + 11.1 + 9 + 5.2 = 48.2 · Decision use: Acceleration candidate, not a confirmed leader: earnings are strong but sector-relative strength is -18.8% and the one-year return is 12.1%. Do not upgrade until sector-relative strength is above zero and another reported period confirms growth. | ||||||
| 14Bio-Techne CorporationTECH | 47.4/100Mixed-negative evidence81% evidence | BREAKING OUT | 17.9/35 Revenue 0.3% · PAT -18.1% · OPM change 12 pp 83% evidence | 12.9/25 ROCE 3.1% · OPM 24.2% 76% evidence | 3.8/20 P/E 75.7× · PEG 7.7 65% evidence | 12.8/20 RS sector -2.5% · RS bench 9.4% · 1Y 43%7 of 12 weeks ahead 100% evidence |
| Exact sum: 17.9 + 12.9 + 3.8 + 12.8 = 47.4 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 15Moderna, Inc.MRNA | 46.7/100Thin evidence · provisional58% evidence | FADING | 18.1/35 Revenue — · PAT — · OPM change 615.4 pp 45% evidence | 6.4/25 ROCE -8.6% · OPM -356.8% 76% evidence | 9.3/20 P/E 44.8× · PEG — 15% evidence | 12.9/20 RS sector 12.5% · RS bench 23.4% · 1Y 118.2%6 of 12 weeks ahead 100% evidence |
| Exact sum: 18.1 + 6.4 + 9.3 + 12.9 = 46.7 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 16BridgeBio Pharma, Inc.BBIO | 44.5/100Mixed-negative evidence61% evidence | BREAKING OUT | 18.2/35 Revenue 100% · PAT — · OPM change 35 pp 62% evidence | 4.8/25 ROCE -16.5% · OPM -54.5% 76% evidence | 10.0/20 P/E — · PEG — 0% evidence | 11.5/20 RS sector -2.5% · RS bench 8.5% · 1Y 76.2%3 of 12 weeks ahead 100% evidence |
| Exact sum: 18.2 + 4.8 + 10 + 11.5 = 44.5 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 17Alnylam Pharmaceuticals, Inc.ALNY | 44.1/100Thin evidence · provisional58% evidence | ASLEEP | 21.6/35 Revenue — · PAT — · OPM change 20 pp 45% evidence | 12.7/25 ROCE 6.3% · OPM 23% 76% evidence | 9.1/20 P/E 56× · PEG — 15% evidence | 0.7/20 RS sector -53% · RS bench -46.1% · 1Y -50.1%0 of 12 weeks ahead 100% evidence |
| Exact sum: 21.6 + 12.7 + 9.1 + 0.7 = 44.1 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 18Cytokinetics, IncorporatedCYTK | 43.9/100Mixed-negative evidence61% evidence | FADING | 21.2/35 Revenue 100% · PAT — · OPM change 8907.6 pp 62% evidence | 4.1/25 ROCE -16.9% · OPM -948.7% 76% evidence | 10.0/20 P/E — · PEG — 0% evidence | 8.6/20 RS sector -1.3% · RS bench 9.6% · 1Y 130.5%10 of 12 weeks ahead 100% evidence |
| Exact sum: 21.2 + 4.1 + 10 + 8.6 = 43.9 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 19Insmed IncorporatedINSM | 42.2/100Mixed-negative evidence61% evidence | BASING | 24.6/35 Revenue 100% · PAT — · OPM change 217.2 pp 62% evidence | 5.4/25 ROCE -9.4% · OPM -50.1% 76% evidence | 10.0/20 P/E — · PEG — 0% evidence | 2.2/20 RS sector -46.4% · RS bench -39.3% · 1Y -9.9%0 of 12 weeks ahead 100% evidence |
| Exact sum: 24.6 + 5.4 + 10 + 2.2 = 42.2 · Decision use: Acceleration candidate, not a confirmed leader: earnings are strong but sector-relative strength is -46.4% and the one-year return is -9.9%. Do not upgrade until sector-relative strength is above zero and another reported period confirms growth. | ||||||
| 20Axsome Therapeutics, Inc.AXSM | 40.0/100Mixed-negative evidence61% evidence | FADING | 16.4/35 Revenue 63.9% · PAT — · OPM change 13.8 pp 62% evidence | 4.5/25 ROCE -20.2% · OPM -33.1% 76% evidence | 10.0/20 P/E — · PEG — 0% evidence | 9.1/20 RS sector -0.4% · RS bench 10.2% · 1Y 102.5%10 of 12 weeks ahead 100% evidence |
| Exact sum: 16.4 + 4.5 + 10 + 9.1 = 40 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 21Arrowhead Pharmaceuticals, Inc.ARWR | 40.0/100Thin evidence · provisional58% evidence | LEADER | 10.6/35 Revenue — · PAT — · OPM change -261.8 pp 45% evidence | 6.6/25 ROCE -8.5% · OPM -191.6% 76% evidence | 9.4/20 P/E 43.4× · PEG — 15% evidence | 13.4/20 RS sector 25.5% · RS bench 37.3% · 1Y 445.6%11 of 12 weeks ahead 100% evidence |
| Exact sum: 10.6 + 6.6 + 9.4 + 13.4 = 40 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 22ABIVAX Société AnonymeABVX | 39.9/100Thin evidence · provisional57% evidence | ASLEEP | 19.8/35 Revenue -66.7% · PAT — · OPM change 564.8 pp 62% evidence | 5.5/25 ROCE -20.6% · OPM — 61% evidence | 10.0/20 P/E — · PEG — 0% evidence | 4.6/20 RS sector -9.2% · RS bench 1% · 1Y 78.5%3 of 12 weeks ahead 100% evidence |
| Exact sum: 19.8 + 5.5 + 10 + 4.6 = 39.9 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 23Revolution Medicines, Inc.RVMD | 39.4/100Thin evidence · provisional53% evidence | LEADER | 9.1/35 Revenue — · PAT — · OPM change -23854 pp 52% evidence | 5.2/25 ROCE -21.3% · OPM — 61% evidence | 10.0/20 P/E — · PEG — 0% evidence | 15.1/20 RS sector 56.1% · RS bench 69.1% · 1Y 452.7%12 of 12 weeks ahead 100% evidence |
| Exact sum: 9.1 + 5.2 + 10 + 15.1 = 39.4 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 24Madrigal Pharmaceuticals, Inc.MDGL | 35.9/100Thin evidence · provisional55% evidence | ASLEEP | 16.2/35 Revenue — · PAT — · OPM change 28 pp 45% evidence | 6.8/25 ROCE -6.7% · OPM -29.8% 76% evidence | 10.0/20 P/E — · PEG — 0% evidence | 2.9/20 RS sector -17.3% · RS bench -7.4% · 1Y 46.8%1 of 12 weeks ahead 100% evidence |
| Exact sum: 16.2 + 6.8 + 10 + 2.9 = 35.9 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 25BioNTech SEBNTX | 35.3/100Mixed-negative evidence64% evidence | BASING | 13.9/35 Revenue 1% · PAT — · OPM change -237.7 pp 62% evidence | 7.6/25 ROCE -3.5% · OPM -456.2% 76% evidence | 8.7/20 P/E 194.3× · PEG — 15% evidence | 5.1/20 RS sector -27% · RS bench -17.4% · 1Y -18.2%0 of 12 weeks ahead 100% evidence |
| Exact sum: 13.9 + 7.6 + 8.7 + 5.1 = 35.3 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 26BioMarin Pharmaceutical Inc.BMRN | 32.5/100Adverse evidence81% evidence | TURNING | 8.7/35 Revenue 9.9% · PAT -48.7% · OPM change -13.1 pp 83% evidence | 10.5/25 ROCE 1.8% · OPM 16.9% 76% evidence | 5.2/20 P/E 41.2× · PEG 5.86 65% evidence | 8.1/20 RS sector -14.4% · RS bench -3.6% · 1Y 5.9%3 of 12 weeks ahead 100% evidence |
| Exact sum: 8.7 + 10.5 + 5.2 + 8.1 = 32.5 · Decision use: Balanced evidence: keep at normal research priority and require another comparable period before raising conviction. | ||||||
| 27Ascendis Pharma A/SASND | 55.4/100Thin evidence · provisional44% evidence | ASLEEP | 25.2/35 Revenue 100% · PAT — · OPM change 113.3 pp 62% evidence | 10.1/25 ROCE 4.7% · OPM 10.1% 76% evidence | 10.1/20 P/E 26.8× · PEG — 15% evidence | 10.0/20 RS sector — · RS bench — · 1Y —2 of 3 weeks ahead 0% evidence |
| Exact sum: 25.2 + 10.1 + 10.1 + 10 = 55.4 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 28Apogee Therapeutics, Inc.APGE | 52.3/100Thin evidence · provisional47% evidence | LEADER | 15.4/35 Revenue — · PAT — · OPM change — 33% evidence | 7.4/25 ROCE -8.5% · OPM — 61% evidence | 10.0/20 P/E — · PEG — 0% evidence | 19.5/20 RS sector 46.5% · RS bench 59.8% · 1Y 279.2%12 of 12 weeks ahead 100% evidence |
| Exact sum: 15.4 + 7.4 + 10 + 19.5 = 52.3 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 29Nuvalent, Inc.NUVL | 46.2/100Thin evidence · provisional47% evidence | 16.3/35 Revenue — · PAT — · OPM change — 33% evidence | 6.5/25 ROCE -10.5% · OPM — 61% evidence | 10.0/20 P/E — · PEG — 0% evidence | 13.4/20 RS sector -1.8% · RS bench 15.9% · 1Y 48.6%5 of 9 weeks ahead 100% evidence | |
| Exact sum: 16.3 + 6.5 + 10 + 13.4 = 46.2 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
| 30Summit Therapeutics Inc.SMMT | 41.6/100Thin evidence · provisional47% evidence | BASING | 12.5/35 Revenue — · PAT — · OPM change — 33% evidence | 17.2/25 ROCE 48.3% · OPM — 61% evidence | 10.0/20 P/E — · PEG — 0% evidence | 1.9/20 RS sector -40% · RS bench -31.3% · 1Y -52%0 of 12 weeks ahead 100% evidence |
| Exact sum: 12.5 + 17.2 + 10 + 1.9 = 41.6 · Decision use: Fill the missing evidence before acting; the ranking is deliberately pulled toward neutral. | ||||||
Missing observations are not scored as bad. Their missing weight lowers confidence and pulls the final score toward neutral. PEG is not shown when the ratio cannot mean anything: the company must be making a profit, its price-to-earnings must be positive, and its three-year earnings growth must fall between 5% and 60%. Dividing a price multiple by a loss, or by growth measured off a tiny base, produces a number that looks precise and tells you nothing. Under relative strength, one mark per week shows the last 12 weeks: a mark is filled where the company led S&P 500 by 5% or more over the 13 weeks ending that week, which is the same test used everywhere on this site. Price stage places the company on the same six-step curve the sector itself is placed on — basing, turning, breaking out, leader, fading, asleep — read from how many weeks running it has led S&P 500 and whether that lead is widening or shrinking. It describes where the PRICE stands, not the earnings trajectory and not a recommendation, and it is left blank for a company whose weekly history is too short or too stale to read.
Frequently asked questions
What is Jazz Pharmaceuticals plc's stock price today?
Jazz Pharmaceuticals plc trades at $262, +126.5% over the past year. The company is valued at $17.0 B. The stock sits at 100% of its 52-week range of $118–$262, +35.9% versus its 200-day average. On the tape, the price is in a confirmed uptrend, 51 weeks in. — as of 5 August 2026.
What were Jazz Pharmaceuticals plc's latest quarterly results?
Jazz Pharmaceuticals plc reported revenue of $1.1 B and net profit of $0.3 B for the Mar 26 quarter. Earnings per share were $4.43. The operating margin was 31.8%, 38.5 pp higher than a year earlier. — as of 5 August 2026.
What is Jazz Pharmaceuticals plc's revenue?
Jazz Pharmaceuticals plc reported revenue of $1.1 B in the Mar 26 quarter, +18.9% year on year. For the full FY25 fiscal year, revenue was $4.3 B (+4.9%). Over the last 4 years revenue compounded at 8.4% a year. — as of 5 August 2026.
What is Jazz Pharmaceuticals plc's profit?
Jazz Pharmaceuticals plc earned $0.3 B of net profit in the Mar 26 quarter. Full-year FY25 profit was $−0.4 B. The operating margin ran 31.8% in the latest quarter. — as of 5 August 2026.
What is Jazz Pharmaceuticals plc's market cap?
Jazz Pharmaceuticals plc's market capitalisation is $17.0 B at a stock price of $262. Market cap is the share price multiplied by shares outstanding, so it is restated whenever the price moves. — as of 5 August 2026.
What is Jazz Pharmaceuticals plc's P/E ratio?
Jazz Pharmaceuticals plc trades at a P/E of 17.9×, at the 49th percentile of its own 2-year range, against a long-run median of 18.1×. This is a comparison with the stock's own history, not a value call — as of 5 August 2026.
Does Jazz Pharmaceuticals plc pay a dividend?
No — Jazz Pharmaceuticals plc has declared no dividend per share in any of its last 12 reported quarters, so there is no payout history and no yield to quote. That is a reading of the filed statements, not an estimate. — as of 5 August 2026.
Is Jazz Pharmaceuticals plc overvalued?
On its own history, Jazz Pharmaceuticals plc looks mid-range against its own history: its P/E of 17.9× sits at the 49th percentile of its 2-year range (long-run median 18.1×). That is a percentile read against the stock's own past, not a price opinion or a direction call. — as of 5 August 2026.
How is Jazz Pharmaceuticals plc performing?
Jazz Pharmaceuticals plc is in a confirmed uptrend, 51 weeks in. Against the S&P 500 it has been ahead on a trailing-13-week view for 24 weeks. This describes what the data did, not a rating. — as of 5 August 2026.
What stage is Jazz Pharmaceuticals plc in?
Turning around — profit growth swung from −43.2% at the trough to +5.3% off a 2-quarter-old trough (single-quarter readings), ROCE holding at 5.9%. The read comes from the last 12 quarters of growth (revenue growth +9.6% latest, profit growth +5.3% latest) plus the ROCE curve, classified by deterministic rules — a trajectory read, not a buy or sell call — as of 5 August 2026.
Is Jazz Pharmaceuticals plc in an uptrend?
Yes — the price is in a confirmed uptrend (week 51 of stage 2), trading +35.9% versus its 200-day average and at 100% of its 52-week range. Price stages cycle base → advance → top → decline, and the stage names where this stock sits in that cycle — as of 5 August 2026.
Is Jazz Pharmaceuticals plc beating the market?
On recent form, yes — Jazz Pharmaceuticals plc has been ahead of the S&P 500 on a trailing-13-week view for 24 straight weeks, the same metric the week-by-week ribbon on this page draws. Separately, on the cumulative view: over the last 10.1 years the stock moved +87% against the S&P 500's +263% — behind the index over the full window. — as of 5 August 2026.
Will Jazz Pharmaceuticals plc's stock price go up?
This page publishes no price forecast for Jazz Pharmaceuticals plc. What it measures instead: the stock price is $262, the price is in a confirmed uptrend 51 weeks in. Its P/E of 17.9× sits at the 49th percentile of its own 2-year range. — as of 5 August 2026.
Is the market betting against Jazz Pharmaceuticals plc?
Somewhat — short interest is 6.3% of Jazz Pharmaceuticals plc's tradable float, about 4.4 days to cover at typical volumes. A moderate reading: some money is positioned against it. With no quarter-by-quarter holder register here, short interest is the cleanest crowd read we hold — as of 5 August 2026.
Does Jazz Pharmaceuticals plc have too much debt?
It is moderate — Jazz Pharmaceuticals plc's debt-to-equity is 0.92. A year-by-year borrowings ladder is not in our numbers for this stock, so the latest reading is the cleanest hold. Read the returns on this page with that leverage in mind — as of 5 August 2026.
What is Jazz Pharmaceuticals plc's capex?
Jazz Pharmaceuticals plc spent $0.0 B on capital expenditure over the last 3 fiscal years, a figure derived from the change in fixed assets plus depreciation. In FY25 alone that was $0.1 B. — as of 5 August 2026.
What is Jazz Pharmaceuticals plc's cash flow?
Jazz Pharmaceuticals plc generated $1.4 B of operating cash flow in FY25 and $1.3 B of free cash flow after $0.1 B of capital spending. Reported profit that year was $−0.4 B, so operating cash ran ahead of profit. — as of 5 August 2026.
Is Jazz Pharmaceuticals plc's profit real cash?
Yes — over the last 2 fiscal years, 254% of Jazz Pharmaceuticals plc's reported profit arrived as operating cash. In FY25, operating cash was $1.4 B against reported profit of $−0.4 B. The cash then goes mostly into building capacity. Cash-flow resolution is annual — as of 5 August 2026.
How financially safe is Jazz Pharmaceuticals plc?
On the balance sheet, the Z-score reads 2.08 — above roughly 3 is safe, below roughly 1.8 is the distress zone. That is in the grey band — neither clearly safe nor clearly distressed. — as of 5 August 2026.
Where is Jazz Pharmaceuticals plc in its business cycle?
Jazz Pharmaceuticals plc's FY25 operating margin was −10.1%, against a 5-year band of −10.1%–17.7%: the low end of its own band, which is where recoveries start when they come. The latest quarter ran 31.8%. Profitability versus a company's own long band is the cleanest cycle clock this page holds — as of 5 August 2026.
What could break the Jazz Pharmaceuticals plc story?
The sharpest disagreement: the price moved +126.5% in a year while annual EPS moved −167.5% — the difference is re-rating, and re-rating has to be repaid with earnings. Mechanically, two Friday closes in a row below the 200-day average would end the price trend — that is the exit rule this page tracks — as of 5 August 2026.
Is Jazz Pharmaceuticals plc a stock worth studying right now?
This is not investment advice. The machine read: Jazz Pharmaceuticals plc's three tracks disagree. Price, valuation and the earnings engine each tell a different story — the next quarter or two settles it. The sharpest open question: whether earnings grow into a price that has already moved. Every number on this page is drawn deterministically from the raw series, with no forecasts and no price opinions — as of 5 August 2026.