Sector Alpha Week of 2026-08-05
Sector Alpha — machine-written from the numbers · Data as of 2026-08-05

Avalo Therapeutics, Inc.

AVTX
Healthcare · Biotechnology

Avalo Therapeutics, Inc.'s three tracks disagree. Price, valuation and the earnings engine each tell a different story — the next quarter or two settles it.

Biggest watch item: the price is already 7 weeks into its uptrend — timing risk, not thesis risk.

The price is in a confirmed uptrend (7 weeks in). Underneath, the last four quarters read mixed. What settles it: the next one or two quarters of delivery.

Price
$18.5
+134.9% 1Y
Revenue (Dec 25)
$0.0 B
Profit (Dec 25)
$−0.0 B
ROE
−89%
FY25
ROIC
−51.5%
vs WACC 8.6% → −60.1 pp
01 · Price story

Price story Before the numbers, the tape. A stock price moves through four repeating seasons: a flat base (stage 1), an advance (2), a top (3), a decline (4). Where the price sits in that cycle frames everything below.

Avalo Therapeutics, Inc. trades at $18.5, in a confirmed uptrend and 7 weeks into that stage. That is +11.9% against its own 200-day average. It sits at 76% of a 52-week range of $9 to $22. On relative strength it is currently behind the S&P 500 on a trailing-13-week view (1 week and counting).

Today the stock is in a confirmed uptrend — week 7 of stage 2. At $18.5 it trades +11.9% versus its 200-day average and sits at 76% of its 52-week range ($9–$22).

Aug 26: $18.5 Weekly closing price ($) with 50- and 200-day averages; shaded bands mark the price stage (grey base, green advance, amber top, red decline). 3-year window.
+11.9% versus the 200-day line, week 7 of stage 2
Price50-day avg200-day avg
S4S4S3S2$910$666$423$180$−63.3$$19$17Jul 23Apr 24Jan 25Oct 25Aug 26
S4S4S3S2$910$666$423$180$−63.3$$19$17Jul 23Jan 25Aug 26
Beating or trailing, week by week since 2016 Each cell is one week from 2016 to now (527 weeks): the stock's trailing 13-week return minus the S&P 500's, green ahead / red behind (±25% ramp). Grey cells are the 13-week warm-up or weeks where the S&P 500 reading is not held.
trailing 13-week return vs the S&P 500
Jul 16Aug 26

Against the market, two honest reads. Cumulative: over the last 10.1 years the stock moved −100% while the S&P 500 moved +263% — behind the index over the full window. Recent form: on a trailing-13-week view the stock is currently behind (1 week and counting; last ahead the week of 2026-07-31) — the ribbon below is that same metric, week by week.

What would end the trend, mechanically: two Friday closes in a row below the 200-day line. That is the exit rule — no debates.

02 · Valuation

Valuation P/E is the price of $1 of annual profit: how many dollars the market pays for each dollar the company earns in a year.

P/E does not price Avalo Therapeutics, Inc. — earnings are negative, so there is no multiple to rank against its own history. The revenue and margin lines below are where a turn, when it comes, would show first. A P/E returns here the first period the bottom line turns positive.

With earnings negative, P/E does not price — there is no multiple to rank against its own history. The revenue and margin lines below are where the turn, when it comes, will show first.

P/E
earnings negative
PEG
n/m
not derivable — 3-year earnings growth unavailable

Put together: the multiple is unremarkable against its own past, so the story rests on the earnings line underneath it, not the multiple.

03 · Stage: No read

Stage: No read Every business sits somewhere on a fundamental arc, and this page names the spot before anything else. The last twelve quarters of revenue, profit and EPS growth — plus the return the business earns on its capital — are read as curves: Deteriorating (the curves are falling), Turning around (a trough has just formed and the last few quarters lift off it), Improving (the climb off the trough is sustained), Consistent (steadily positive with healthy returns), Topping out (still high but decelerating from the peak). When the curves genuinely disagree the read is Mixed; too little history is No read.

Avalo Therapeutics, Inc. reads as no read on its fundamental arc. Under eight usable quarters on the growth trio — not enough history for an honest trajectory read. The read is built from 9 quarters across 1 curve, on partial evidence.

Growth, year by year: revenue −100.0% in FY23 Year-over-year growth per fiscal year, %: revenue (left axis); net profit and EPS (right axis — profit growth swings far wider). Zero line drawn.
Revenue YoY
116%58%0.0%−58%−116%%−100%FY21FY23FY25
116%58%0.0%−58%−116%%−100%FY21FY23FY25
Three growth curves, twelve quarters Year-on-year growth of trailing-twelve-month revenue (left axis), profit and EPS (right axis — they swing far wider), % at each quarter-end. A missing point means that reading is not held for the quarter.
the trajectory the stage is read from
Revenue
−98.8%−99.4%−100.0%−100.6%−101.2%%−100%Dec 21Mar 23Dec 25
−98.8%−99.4%−100.0%−100.6%−101.2%%−100%Dec 21Mar 23Dec 25
ROCE Trailing-twelve-month operating profit (before interest and tax) as a share of average capital employed — total assets minus current liabilities, the standard textbook basis, %.
the return curve, computed quarterly
ROCE
−86%−138%−190%−242%−294%%−100%Dec 21Jun 22Mar 23Dec 23Dec 25
−86%−138%−190%−242%−294%%−100%Dec 21Mar 23Dec 25
ROCE
Rising
latest −100.0% · span −280.0%–−100.0%

Why it matters: with too little history, an honest page says so instead of guessing a trajectory.

Fewer than eight usable quarters on the growth curves — this page will not guess a trajectory from a stub of history.

04 · 4-Factor Sector Score

4-Factor Sector Score

No sector-relative score — Avalo Therapeutics, Inc. is not among the largest members shown in this industry comparison for Biotechnology.

The score is a rank WITHIN a peer set: every metric is scored by percentile against the other members. Without the peer set there is no score to state, so none is invented here.

05 · Revenue

Revenue Revenue is the top line: everything the company billed its customers in the period.

Avalo Therapeutics, Inc. reported $0.0 B of revenue in the Dec 25 quarter. The last full year, FY25, came in at $0.0 B. The last four reported quarters add to $0.0 B. A multi-year compound rate is not shown because the annual history behind it is too short to compute one honestly.

FY25 revenue came in at $0.0 B (null on the year). The latest quarter (Dec 25) printed $0.0 B, null year on year.

FY25 revenue $0.0 B (null YoY) Revenue bars, $ B (left); YoY growth-% line (right). 5-year window. A bar is red when it is lower than the year before.
RevenueYoY growth
0.022116%0.01658%0.0110.0%0.005−58%0.000−116%$ B%$0B−100%FY21FY23FY25
0.022116%0.01658%0.0110.0%0.005−58%0.000−116%$ B%$0B−100%FY21FY23FY25
Dec 25: $0.0 B (null YoY) Quarterly revenue bars, $ B (left); YoY growth-% line (right). Last 12 quarters. A bar is red when it is lower than the quarter before.
Revenue (quarterly)YoY growth
0.011−98.8%0.008−99.4%0.005−100.0%0.003−100.6%0.000−101.2%$ B%$0B−100%Dec 21Mar 23Dec 25
0.011−98.8%0.008−99.4%0.005−100.0%0.003−100.6%0.000−101.2%$ B%$0B−100%Dec 21Mar 23Dec 25
06 · Operating margin

Operating margin Operating margin is what is left of every $100 of sales after running the business, before interest and tax. It is the cleanest read on pricing power and cost control.

A clean operating margin is not in our numbers for Avalo Therapeutics, Inc. — its accounts do not report the operating-profit line this section reads, which is common for lenders and holding companies. The sections above and below carry the readings this company's filings do support.

This company's accounts do not report the operating-profit line this section reads — common for lenders and holding companies classified outside the financial bucket. The revenue and net-profit sections are the cleaner reads for Avalo Therapeutics, Inc..

Why: the numbers show the operating margin move clearly, but the cost lines behind it sit below what we hold — so we state the move without inventing its driver.

FY22: −200.0% Operating margin by fiscal year, %, line (left); year-on-year change in the margin, in percentage points, line (right). 2-year window.
within a −800.0–−200.0% band over 2 years
operating marginYoY change (pp)
−152%601.2%−326%600.6%−500%600.0%−674%599.4%−848%598.8%%%−200%600%FY21FY22
−152%601.2%−326%600.6%−500%600.0%−674%599.4%−848%598.8%%%−200%600%FY21FY22
Dec 25: null% operating margin (null pp YoY) Quarterly operating margin, %, line (left); year-on-year change in the margin, in percentage points, line (right). Last 12 quarters. Operating profit as a share of revenue, per quarter.
Operating margin
1.2%0.6%0.0%−0.6%−1.2%%0%Dec 21Mar 23Dec 25
1.2%0.6%0.0%−0.6%−1.2%%0%Dec 21Mar 23Dec 25
07 · Net profit

Net profit Net profit is what survives every cost, interest and tax — the number EPS, dividends and book value all grow from.

Avalo Therapeutics, Inc. posted a net loss of $0.01 B in the Dec 25 quarter. The full FY25 year was a loss of $0.1 B. The same quarter a year earlier lost $0.01 B. 10 of the last 12 reported quarters were loss-making.

Dec 25 profit was $−0.0 B, null year on year. On the full year, FY25 printed $−0.1 B (null).

FY25 profit $−0.1 B (null YoY) Net profit bars, $ B (left); YoY growth-% line (right). 5-year window. A bar is red when it is lower than the year before.
Net profit
0.01−0.02−0.04−0.06−0.09$ B$−0BFY21FY23FY25
0.01−0.02−0.04−0.06−0.09$ B$−0BFY21FY23FY25
Dec 25: $−0.0 B (null YoY) Quarterly net profit bars, $ B (left); YoY growth-% line (right). Last 12 quarters. A bar is red when it is lower than the quarter before.
Net profit (quarterly)
0.020.01−0.01−0.03−0.04$ B$0BDec 21Mar 23Dec 25
0.020.01−0.01−0.03−0.04$ B$0BDec 21Mar 23Dec 25
08 · Cash flow — the router

Cash flow — the router The P&L says what was earned; the cash-flow statement says what actually arrived. Operating cash flow (CFO) against profit is the cleanest lie detector in the accounts.

Avalo Therapeutics, Inc.'s cash-flow history is too thin to judge how much reported profit converts into cash. In FY25 that was $−0.1 B of operating cash against $−0.1 B of profit. After null of capital spending, $−0.1 B was left as free cash. Cash resolution here is annual, because quarterly cash statements are not published.

FY25: operating cash of $−0.1 B against reported profit of $−0.1 B, leaving free cash of $−0.1 B after null of capital spending.

Cash-flow readings here are annual — that is the resolution our series carries, so this section moves once a year.

FY25: CFO $−0.1 B vs profit $−0.1 B Operating cash flow and net profit by fiscal year, $ B; the line is free cash flow (CFO minus capital spending). 5-year window, annual resolution.
Operating cashNet profitFree cash
0.01−0.02−0.04−0.06−0.09$ B$−0B$−0B$−0BFY21FY23FY25
0.01−0.02−0.04−0.06−0.09$ B$−0B$−0B$−0BFY21FY23FY25
Mar 26: operating cash $−0.0 B Operating cash per quarter, $ B (bars); conversion = operating cash as % of net profit (line, right). Last 12 quarters. Dashed line = 100%.
Operating cash (quarterly)Conversion100%
0.002112%−0.00469%−0.01025%−0.016−19%−0.022−62%$ B%$0B−50%Jun 23Sep 24Mar 26
0.002112%−0.00469%−0.01025%−0.016−19%−0.022−62%$ B%$0B−50%Jun 23Sep 24Mar 26

Router verdict: the visible cash user is investment — the next section checks what the spending is buying.

09 · Where the cash goes

Where the cash goes Working capital is the cash tied up between paying suppliers and getting paid: debtor days (customers owe), inventory days (stock waits), and the cash conversion cycle (the whole loop, in days of sales).

Avalo Therapeutics, Inc. does not report the debtor, inventory and payable day-counts a cash cycle is built from, so this section reads the investment side instead. Capital spending ran $0.0 B over the last 3 years. Nothing is estimated in place of the missing day-counts, so no cash-cycle chart is drawn.

Working-capital day-counts are not in our numbers for this stock, so this section reads the investment side — where the cash is being put to work.

On the investment side: capital spending of $0.0 B over the last 3 fiscal years.

FY23: capex $0.0 B Capital spending per fiscal year, $ B (bars).
steady investment
Capex
1.20.60.0−0.6−1.2$ B$0BFY21FY22FY23
1.20.60.0−0.6−1.2$ B$0BFY21FY22FY23
Dec 23: capex $0.0 B in the quarter Capital spending per quarter, $ B (bars, left); free cash flow, $ B (line, right). Last 9 quarters.
Capex (quarterly)Free cash
1.20.0120.60.0040.0−0.005−0.6−0.014−1.2−0.022$ B$ B$0B$0BJun 21Dec 22Dec 23
1.20.0120.60.0040.0−0.005−0.6−0.014−1.2−0.022$ B$ B$0B$0BJun 21Dec 22Dec 23

The synthesis: the cash is going into capacity, not disappearing into the cycle — the question becomes whether the new capacity earns.

10 · Return on equity

Return on equity Return on equity (ROE) is the profit the business earns on its shareholders’ money. With the full capital-employed split not in our numbers, ROE is the cleanest long ladder we can draw here.

Avalo Therapeutics, Inc. earns a ROE of −100% in FY25. That is up from a trough of −400% in FY21. Return on invested capital clears the cost of that capital by −60.1 percentage points, so growth here is not yet paying for the capital it uses. The wiring behind it is −200.0% net margin on 0.67× asset turns.

FY25 ROE is −100%, recovered from a FY21 trough of −400% — the full ladder below shows the fall and the climb, undoctored.

🚨 Why the return is what it is — the wiring (FY22): −200.0% net margin × 0.67× asset turns × −3.00× balance-sheet leverage ≈ 402.0% on equity. Margin does its share; leverage is modest — this is an earned return, not a borrowed one.

The capstone test — ROIC − WACC: −51.5% − 8.6% = a −60.1 pp spread. The 8.6% is an estimate of this company's own cost of capital — read the sign and the size of the spread, not the decimals. Negative — growth at these returns destroys value until the returns recover.

FY25: ROE −100% Return on equity by fiscal year, % (line); ROIC by fiscal year, % (line). 5-year window, dips included. Dashed line = the 8.6% cost of capital used on this page.
the climb back from FY21's −400%
ROEROIC (annual)WACC
620%−178%−975%−1,773%−2,570%%−100%−491.2%FY21FY23FY25
620%−178%−975%−1,773%−2,570%%−100%−491.2%FY21FY23FY25
Dec 23: ROIC −320.0% (TTM) vs WACC 8.6% Trailing-twelve-month ROIC and ROE, per quarter, %; dashed line = the cost of capital. Last 12 quarters, put on a trailing-twelve-month basis and anchored to the annual figure.
ROIC (TTM)ROE (TTM)WACC
661%−96%−853%−1,611%−2,368%%−320%−20.6%Jun 23Sep 24Mar 26
661%−96%−853%−1,611%−2,368%%−320%−20.6%Jun 23Sep 24Mar 26
11 · Dividend

Dividend

Avalo Therapeutics, Inc. pays no dividend. Across the last 12 reported quarters it has declared no dividend per share, so there is no payout history to chart and no yield to quote. Companies at this stage typically reinvest earnings rather than distribute them, which makes the cash-flow and reinvestment sections the place that cash shows up.

Avalo Therapeutics, Inc. does not currently pay a dividend. Across the last 12 reported quarters the company has declared no dividend per share, so there is no payout history to chart and no yield to quote. Companies at this stage typically reinvest earnings instead of distributing them.

12 · Debt

Debt Debt-to-equity says how much of the business is funded by borrowings. Low is the safe corner; the trend matters as much as the level.

Avalo Therapeutics, Inc. carries total debt of $0.0 B against shareholder equity of $0.1 B as of Mar 26, a debt-to-equity of 0.00 — effectively unlevered. On the annual view that ratio went from 1.50 in FY21 to 0.00 in FY25. The returns elsewhere on this page are therefore earned rather than borrowed.

Mar 26: total debt of $0.0 B against shareholder equity of $0.1 B — a debt-to-equity of 0.00. On the annual view, debt-to-equity went from 1.50 (FY21) to 0.00 (FY25). The returns on this page are earned, not borrowed.

FY25: debt $0.0 B at 0.00× equity Total debt by fiscal year, $ B (bars); debt-to-equity, × (line). 5-year window.
Total debtDebt-to-equity
0.0321.8×0.0240.8×0.016−0.3×0.008−1.3×0.000−2.3×$ B×$0B0.00×FY21FY23FY25
0.0321.8×0.0240.8×0.016−0.3×0.008−1.3×0.000−2.3×$ B×$0B0.00×FY21FY23FY25
Mar 26: debt $0.0 B, debt-to-equity 0.00 Total debt per quarter, $ B (bars); debt-to-equity, × (line). Last 12 quarters.
Total debt (quarterly)Debt-to-equity
0.0110.1×0.008−0.2×0.005−0.5×0.003−0.8×0.000−1.1×$ B×$0B0.00×Jun 23Sep 24Mar 26
0.0110.1×0.008−0.2×0.005−0.5×0.003−0.8×0.000−1.1×$ B×$0B0.00×Jun 23Sep 24Mar 26
13 · Ownership

Ownership There is no quarter-by-quarter holder register to read here, so we read the crowd through short interest — the slice of tradable shares currently sold short, positioned for a fall.

31.2% of Avalo Therapeutics, Inc.'s tradable float is currently sold short — a large bloc is positioned against it. At typical trading volumes those positions would take about 6.3 days to buy back. There is no quarter-by-quarter holder register to read for this filer, so the crowd is read through short interest instead.

The latest reading: 31.2% of the float is sold short, and at typical trading volumes it would take about 6.3 days to buy those positions back. A large bloc is positioned against it. This is a single point-in-time reading — we do not yet hold its history, so we show no trend chart.

Short interest
31.2%
of the tradable float
Days to cover
6.3
at typical volumes

Why it sits there: who is doing the shorting, and why, does not travel with the number — the level is shown without inventing its story.

14 · Safety line

Safety line The Z-score estimates how far a company sits from balance-sheet distress — above roughly 3 is safe, below roughly 1.8 is the danger zone. It was built for manufacturers, so it is not applied to banks and lenders.

Avalo Therapeutics, Inc.: the Z-score reads −4.80. A Z-score above roughly 3 reads as safe and below roughly 1.8 as the distress zone, so this sits inside the distress zone. It is a distance-to-distress estimate from the balance sheet, not a forecast of failure.

🚨 Why it matters: a Z-score of −4.80 is inside the distress zone — the balance sheet is a real risk, not a detail.

The safety line in one sentence: the Z-score reads −4.80.

15 · Related companies

No sector comparison is shown here — not among the largest members shown in this industry comparison.

16 · Frequently asked questions

Frequently asked questions

What is Avalo Therapeutics, Inc.'s stock price today?

Avalo Therapeutics, Inc. trades at $18.5, +134.9% over the past year. The company is valued at $1.0 B. The stock sits at 76% of its 52-week range of $9–$22, +11.9% versus its 200-day average. On the tape, the price is in a confirmed uptrend, 7 weeks in. — as of 5 August 2026.

What were Avalo Therapeutics, Inc.'s latest quarterly results?

Avalo Therapeutics, Inc. reported revenue of $0.0 B and a net loss of $0.0 B for the Dec 25 quarter. Earnings per share were $−0.37. — as of 5 August 2026.

What is Avalo Therapeutics, Inc.'s revenue?

Avalo Therapeutics, Inc. reported revenue of $0.0 B in the Dec 25 quarter. For the full FY25 fiscal year, revenue was $0.0 B. — as of 5 August 2026.

What is Avalo Therapeutics, Inc.'s profit?

Avalo Therapeutics, Inc. earned $−0.0 B of net profit in the Dec 25 quarter. Full-year FY25 profit was $−0.1 B. — as of 5 August 2026.

What is Avalo Therapeutics, Inc.'s market cap?

Avalo Therapeutics, Inc.'s market capitalisation is $1.0 B at a stock price of $18.5. Market cap is the share price multiplied by shares outstanding, so it is restated whenever the price moves. — as of 5 August 2026.

Does Avalo Therapeutics, Inc. pay a dividend?

No — Avalo Therapeutics, Inc. has declared no dividend per share in any of its last 12 reported quarters, so there is no payout history and no yield to quote. That is a reading of the filed statements, not an estimate. — as of 5 August 2026.

How is Avalo Therapeutics, Inc. performing?

Avalo Therapeutics, Inc. is in a confirmed uptrend, 7 weeks in. Against the S&P 500 it has been behind on a trailing-13-week view for 1 week. This describes what the data did, not a rating. — as of 5 August 2026.

Is Avalo Therapeutics, Inc. in an uptrend?

Yes — the price is in a confirmed uptrend (week 7 of stage 2), trading +11.9% versus its 200-day average and at 76% of its 52-week range. Price stages cycle base → advance → top → decline, and the stage names where this stock sits in that cycle — as of 5 August 2026.

Is Avalo Therapeutics, Inc. beating the market?

Not lately — on a trailing-13-week view Avalo Therapeutics, Inc. is currently behind the S&P 500 (1 week and counting; last ahead the week of 2026-07-31), the same metric the week-by-week ribbon on this page draws. Separately, on the cumulative view: over the last 10.1 years the stock moved −100% against the S&P 500's +263% — behind the index over the full window. — as of 5 August 2026.

Will Avalo Therapeutics, Inc.'s stock price go up?

This page publishes no price forecast for Avalo Therapeutics, Inc. What it measures instead: the stock price is $18.5, the price is in a confirmed uptrend 7 weeks in. Direction is not something this site claims to know. — as of 5 August 2026.

Is the market betting against Avalo Therapeutics, Inc.?

Yes — short interest is 31.2% of Avalo Therapeutics, Inc.'s tradable float, about 6.3 days to cover at typical volumes. A crowded short: a large bloc is positioned against it. With no quarter-by-quarter holder register here, short interest is the cleanest crowd read we hold — as of 5 August 2026.

What is Avalo Therapeutics, Inc.'s capex?

Avalo Therapeutics, Inc. spent $0.0 B on capital expenditure over the last 3 fiscal years, a figure derived from the change in fixed assets plus depreciation. In FY23 alone that was $0.0 B. — as of 5 August 2026.

What is Avalo Therapeutics, Inc.'s cash flow?

Avalo Therapeutics, Inc. generated $−0.1 B of operating cash flow in FY25 and $−0.1 B of free cash flow after null of capital spending. Reported profit that year was $−0.1 B, so operating cash ran ahead of profit. — as of 5 August 2026.

How financially safe is Avalo Therapeutics, Inc.?

On the balance sheet, the Z-score reads −4.80 — above roughly 3 is safe, below roughly 1.8 is the distress zone. That is inside the danger band — a real balance-sheet risk. — as of 5 August 2026.

Where is Avalo Therapeutics, Inc. in its business cycle?

Avalo Therapeutics, Inc.'s FY22 operating margin was −200.0%, against a 2-year band of −800.0%–−200.0%: mid-band by its own history — neither the peak that precedes mean-reversion nor the trough that precedes recovery. Profitability versus a company's own long band is the cleanest cycle clock this page holds — as of 5 August 2026.

What could break the Avalo Therapeutics, Inc. story?

Biggest watch item: the price is already 7 weeks into its uptrend — timing risk, not thesis risk. Mechanically, two Friday closes in a row below the 200-day average would end the price trend — that is the exit rule this page tracks — as of 5 August 2026.

Is Avalo Therapeutics, Inc. a stock worth studying right now?

This is not investment advice. The machine read: Avalo Therapeutics, Inc.'s three tracks disagree. Price, valuation and the earnings engine each tell a different story — the next quarter or two settles it. The sharpest open question: the next one or two quarters of delivery. Every number on this page is drawn deterministically from the raw series, with no forecasts and no price opinions — as of 5 August 2026.

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