# Septerna share price today (Septerna, Inc., SEPN)

> Septerna, Inc.'s share price, valuation and earnings point in different directions. The next one or two quarters should make it clearer. SEPN · Healthcare · Biotechnology · data as of 5 November 2026. Page: https://www.sectoralpha.in/us/stocks/sepn

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## Key numbers

- Price: $47.35 (+155.8% in a year)
- Revenue (Jun 2026): $26.7 M
- Profit (Jun 2026): −$13.0 M
- Operating margin: −62.9% (+24,288.4 points on a year ago)

Biggest thing to watch: the price is not yet in a clear uptrend, so timing is the risk more than the business. ## What is the Septerna share price today? Septerna, Inc.'s share price was $47.35 at the close on 5 November 2026. That is 45.9% above its average price over the last 200 trading days. In the last 52 weeks it traded between $19 and $47, and at that close it was at the high of that range. Over the past 13 weeks it has done better than the S&P 500, and it has stayed ahead for 6 weeks in a row. Over the last 1 year the share price moved +304% while the S&P 500 moved +18%, so it is ahead of the index over that whole period. The chart above shows the 13-week comparison for every week. This page treats a rise as over when the price closes below its 200-day average on two Fridays in a row. ## What dividend does Septerna pay? Septerna, Inc. pays no dividend. In the last 12 reported quarters it declared no dividend per share, so there is no payout history to chart and no yield to show. Companies like this usually keep their earnings in the business, so the cash-flow sections show where that cash goes. ## Which stock lists is Septerna on? Septerna is not in the Nasdaq 100, the S&P 500 or the Dow Jones 30, and is not on the US tech stocks list. ## Is Septerna profitable? Septerna, Inc. posted a net loss of $13.0 M in the Jun 2026 quarter. The full FY25 year was a loss of $48.9 M. That loss is 48.7% of the quarter's revenue. The same quarter a year earlier lost $24.8 M. 10 of the last 12 reported quarters were loss-making. ## How much revenue does Septerna make, and is it growing? Septerna, Inc. reported $26.7 M of revenue in the Jun 2026 quarter. Over 2 years it has grown 1,644.5% a year on average. The last full year, FY25, came in at $46.0 M. The last four reported quarters add to $98.9 M. FY25 revenue was $46.0 M, +4,174.5% on the year before. Recent pace: the last four quarters grew +11,800.2% on average, against 1,644.5% a year over the longer run, so this year is growing faster than its own long-run rate. Is growth speeding up? Revenue over the last 12 months grew +13,520.1%, against +986.3% a year over the last 8 quarters (accelerating). ## How much of every $100 of sales does Septerna keep? Septerna, Inc.'s operating margin was −62.9% in the Jun 2026 quarter, 24,288.4 percentage points higher than the same quarter a year ago. Across 3 years it has been between −30,165.6% and −175.8%. The latest quarter is above every full year in that period. Why the margin moved: operating margin changed +24,288.4 percentage points on the year while gross margin changed +0.0 points. So the gain came mostly from costs below the gross margin, such as staff and overheads, measured against sales. ## Is Septerna's profit turning into cash? Septerna, Inc.'s cash-flow history is too short to judge how much of its profit turns into cash. In FY25 it brought in $110 M of operating cash against −$48.9 M of profit. After $518 K of spending on assets, $110 M was left over as free cash. Cash-flow figures here are yearly, because quarterly cash statements are not published, so this section changes once a year. What to look at next: the main use of cash is spending on assets. The next section checks what that spending is building. ## Where does Septerna's cash go? Septerna, Inc. does not report the customer, stock and supplier day counts a cash cycle needs, so this section looks at its spending on assets instead. It spent $5.5 M on assets over the last 3 years. Averaged over those years that is 4.0% of FY25 revenue a year. Nothing is estimated in place of the missing day counts, so no cash-cycle chart is drawn. Spending on assets: $5.5 M over the last 3 years. In short: most of the cash goes on covering the loss, not on new assets; spending on assets is small next to it. ## What is Septerna's P/E ratio, and how does it compare with its own history? Septerna, Inc. has no P/E right now, because its earnings are negative. The revenue and margin sections are where a turn would show first. Measured against sales instead, the market values Septerna, Inc. at 48.1× its FY25 revenue of $46.0 M. The P/E comes back here once profit turns positive. ## Is the Septerna business getting better or worse? Septerna, Inc.'s business trend cannot be read yet. There are fewer than eight usable quarters of growth figures, so there is not enough history to read the trend. This is based on 7 quarters of 1 measure, with some gaps. Why it matters: with too little history, we say so rather than guess a direction. One or more growth lines have an extreme jump caused by comparing with a near-zero or loss-making quarter. Those jumps are capped before reading and drawn at the edge of the chart, so one odd quarter does not decide the result. The return figures here are yearly, not quarterly. They show level and direction only; they can support the growth lines but never decide the reading alone. There are fewer than eight usable quarters, so this page does not guess a direction from so little history. ## How much does Septerna earn on its capital? Septerna, Inc. earned a ROE of −13% in FY25. That is up from a low of −17% in FY24. Its return on capital used (ROIC) is left out: on sales this small it reads −4,692%, a number that says nothing useful about the business. It comes from a −106.4% net margin and 0.08× asset turnover (sales divided by assets). Why the return is what it is (FY25): a −106.4% net margin × 0.08× asset turnover × 1.56× leverage (assets divided by equity) ≈ −13.3% on equity. The margin does its share; borrowing plays a small part, so this return is earned, not borrowed. ## Does Septerna have too much debt? Septerna, Inc. has total debt of $22.5 M against shareholder equity of $387 M as of Jun 2026, so its debt is 0.06× its equity, which is very little. Year by year, that ratio went from 0.02 in FY22 to 0.06 in FY25. So the returns on this page come from the business, not from borrowed money. ## What is the Septerna shareholding pattern? 13.3% of Septerna, Inc.'s tradable shares are in short positions, which are bets that the price will fall, so a large group of traders is betting against it. At normal trading volumes, closing those positions would take about 8.7 days. US companies do not publish a quarter-by-quarter list of owners, so this page uses short interest instead. It is a single reading at one point in time; we do not have its history. Why it is at this level: the figure does not say who holds the short positions or why, so we show the level without guessing the story. ## How far is Septerna from balance-sheet trouble? For Septerna, Inc., the Z-score is 3.46. A Z-score above about 3 is safe and below about 1.8 signals danger, so this is well clear of danger. It estimates how far the balance sheet is from trouble; it is not a forecast of failure. Why it matters: a Z-score of 3.46 is well clear of the danger zone, so the balance sheet is not the risk here. ## How does Septerna rank in its industry? There is no score against its industry: Septerna, Inc. is not among the largest members shown in this industry comparison for Biotechnology. The score ranks a company within its industry: each measure is scored against the other members. Without that group there is no score, so none is shown. ## Which companies is Septerna compared with? No sector comparison is shown here, not among the largest members shown in this industry comparison. ## Which companies are close to Septerna in size? Septerna is the 70th largest of 211 Biotechnology companies on Sector Alpha by market value (scores of 5 November 2026). Just above it: Arcus Biosciences, Inc., NewAmsterdam Pharma Company N.V. and Celldex Therapeutics, Inc. Just below it: Recursion Pharmaceuticals, Inc., Aurinia Pharmaceuticals Inc. and Lakefront Biotherapeutics NV. ### Biotechnology companies close in size

1. [Arcus Biosciences, Inc.](https://www.sectoralpha.in/us/stocks/rcus) $2.5 billion
2. [NewAmsterdam Pharma Company N.V.](https://www.sectoralpha.in/us/stocks/nams) $2.3 billion
3. [Celldex Therapeutics, Inc.](https://www.sectoralpha.in/us/stocks/cldx) $2.2 billion
4. Septerna, Inc. $2.2 billion
5. [Recursion Pharmaceuticals, Inc.](https://www.sectoralpha.in/us/stocks/rxrx) $2.2 billion
6. [Aurinia Pharmaceuticals Inc.](https://www.sectoralpha.in/us/stocks/auph) $2.2 billion
7. [Lakefront Biotherapeutics NV](https://www.sectoralpha.in/us/stocks/lkft) $2.2 billion

[All 211 Biotechnology companies, largest first](https://www.sectoralpha.in/us/sectors/biotechnology#all-companies)

### Companies close in size in other industries

1. [Intuitive Machines, Inc.](https://www.sectoralpha.in/us/stocks/lunr) $2.3 billion · Aerospace & Defense
2. [Pelagos Insurance Capital Limited](https://www.sectoralpha.in/us/stocks/plgo) $2.3 billion · Insurance - Diversified
3. Septerna, Inc. $2.2 billion
4. [Trulieve Cannabis Corp.](https://www.sectoralpha.in/us/stocks/trlv) $2.2 billion · Drug Manufacturers - Specialty & Generic
5. [Federal Agricultural Mortgage Corporation](https://www.sectoralpha.in/us/stocks/agm) $2.2 billion · Credit Services

## What else do people ask about Septerna? ### What were Septerna's latest quarterly results? Septerna, Inc. reported revenue of $26.7 M and a net loss of $13.0 M for the Jun 2026 quarter. Earnings per share were −$0.29. The operating margin was −62.9%, 24,288.4 percentage points higher than a year earlier (as of 5 November 2026). ### What is Septerna's market cap? Septerna, Inc.'s market capitalisation is $2.2 B at a stock price of $47.35. Market cap is the share price times the number of shares, so it changes whenever the price moves (as of 5 November 2026). ### How is Septerna performing? Septerna, Inc.'s latest readings are below. Over the past 13 weeks it has done better than the S&P 500, for 6 weeks running. This describes what the data did, not a rating (as of 5 November 2026). ### Will Septerna's stock price go up? This page does not forecast Septerna, Inc.'s stock price. What it shows instead: the stock price is $47.35. Nobody can reliably say which way a price will move, and this site does not try (as of 5 November 2026). ### Where is Septerna in its business cycle? Septerna, Inc.'s FY25 operating margin was −175.8%, against a 3-year range of −30,165.6% to −175.8%: the middle of its own range, neither a peak nor a low. The latest quarter was −62.9%. Comparing margins with a company's own long history is a good way to see where it is in its cycle (as of 5 November 2026). ### What could break the Septerna story? Biggest thing to watch: the price is not yet in a clear uptrend, so timing is the risk more than the business. On price, this page treats a rise as over when the share price closes below its 200-day average on two Fridays in a row (as of 5 November 2026). ### Is Septerna a stock worth studying right now? What the numbers show: Septerna, Inc.'s share price, valuation and earnings point in different directions. The next one or two quarters should make it clearer. The main open question: the next one or two quarters of results. Every number on this page is worked out by code from the published figures, with no forecasts and no price opinions (as of 5 November 2026). This is research, not advice. We’re not SEBI-registered.